پاورپوینت کامل An introduction to future drug delivery system 19 اسلاید در PowerPoint

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پاورپوینت کامل An introduction to future drug delivery system 19 اسلاید در PowerPoint

اسلاید ۴: Nanotube:Quantum Dots:

اسلاید ۵: Nanoshells(NS):These are another recent invention.NS are miniscule beads coated with gold.The most useful nanoshells are those that absorb near infrared light that can easily penetrateSeveral centimeters in human tissuses.Absorption of light by nanoshells creates an intense heat that is lethal to cells.In laboratory cultures the heal generated by the light-absorbing nanoshells has successfullyKilled tumor cells while leaving neighboring cells intact. Liposomes:Liposomes are self-assembling spherical closed colloidal structures composed of lipid bilayersThat surround a central aqueous space.Liposome based formulations of several anticancer agents have been approved for theTreatment of metastatic breast cancer and Kaposi’s sarcoma.

اسلاید ۶: Liposomes:

اسلاید ۷: Nanoshells:

اسلاید ۸: Caltilevers:Tiny bars anchored at one end can be engineered to bind to molecules associated with cancerIt would be possible to tell whether the cancer molecules are present and hence detect earlyEvents in the development of cancer cells. Dendrimer:A number of nanoparticles that will facilitate drug delivery are being developed.It is hoped dendrimers can be manipulated to release their contents only in the presence ofCertain trigger molecu;es associated with cancer.following drug releases the dendrimers mayAlso report bacj whether they are successfully killing their targets. Nanopores:Nanopores(holes)allow DNA to pass through one strand at a time hence DNA sequencing canBe made more efficient.The passage of DNA through a nano pore can be used to decipher the encoded informationIncluding errors in the code known to be associated with cancer.

اسلاید ۹: Cantilevers:

اسلاید ۱۰: Dendrimers:

اسلاید ۱۱: Nanopores:

اسلاید ۱۲: Fluorescent Nanoparticles:The diagnosis and treatment of cancer have been greatly improved with the recent Developments in nanotechnology one of the promising nanoscale tools for cancer diagnosis isFluorescent nanoparticles(NPs) such as organic dye-dope NPs quantum dots and upconversionNPs that enable highly sensitive optical imaging of cancer at cellular and animal level. Monoclonal antibodies and Nanobodies:In the past decades the mainstay of systemic therapy for solid and haematology malignancies Was chemotherapy nevertheless this modality has the drawbacks such as drug resistance andEliciting sever cytotoxicity in normal tissue.The therapeutic monoclonal antibodies(mAbs) are deemed to be a class of novel agents thatCan specifically target and disrupt molecular pathways underlying tumorigenesis.the mAbs areProduced by a single clone of B-cells and are monospecific and homogeneous.The recombinant antibodies have been reduced in size rebuilt into multivalent moleculesAnd fused with different moities such as radionuclides toxins enzymes.Focuses on implementation of the mAbs and nanobodies fragments for cancer therapy.Recent advances in nanothechnology in cancer Treatment:

اسلاید ۱۳: ۳)Nanomedicine:Nanothechnology has been extensively merging into biomedical research to develop a new Research field Nanomedicine.The effects of gastrin messenger RNA(mRNA) down-regulation on growth of human pancreaticCancer Gastrin expression was examined in human pancreatic cancer cell lines by reverse Transcriptase-polymerase chain reaction and peptide expression was assessed by immunocytochemistery Gastrin was down-regulated using either stable transfection of an antisense gastrin cDNAOr 1 of 3 shRNA(short hairpin RNA) constructs Stable transfection in gastrin antisense or shRNAsInto BxPC-3 cells resulted in clones with more than 90% reduction in gastrin mRNAImmunofluorescence analysis confirmed that gastrin peptide levels were decreased in antisenseAnd shRNA tumors.4)Nanomicelles:Emerging nanotechnology has already developed various innovative nanomedicinesSelf-assemblies of block copolymers are promising nanomedicines for targeted drug delivery andImaging stimulus-responsive targeted nanomicelles are designed to release drugs on based onStimuli such as PH temperature redox potential magnetism and ultrasoun