پاورپوینت کامل Chinese Medicine 50 اسلاید در PowerPoint
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پاورپوینت کامل Chinese Medicine 50 اسلاید در PowerPoint
اسلاید ۴: Chemical(s)IndicationClinical StageDHPG (Gancyclovir)*CMVApproved3TC (Lamivudine)*HBVApprovedL-FTC (Emtricitabine)HBVPhase III (completed)L-FMAU (Clevudine)HBVApprovedL-OddC (Troxacitabine)Solid TumorPhase I/IIL-Fd4C (Elvucitabine)HIVHBVPhase IIPhase I/IID-IPdR (Ropidoxuridine)Radiosensitizer For solid tumorPhase I/IIOrphan Drug StatusD-4’Ed4THIVPreclinicalPHY-906CancerPhase II * Do Not Hold Patent * Do Not Hold Patent * Do Not Hold PatentChemicals Discovered in this Laboratory (In Collaboration with Others) Under Different Stages of Clinical Development
اسلاید ۵: Nature Product Analogs Under Current InvestigationCamptothecin and VP-16 conjugates CancerTylophorine analogsCancer and autoimmune diseasesHelioxanthin analogsHepatitis B VirusFalvanoid analogsFacilitator of oral uptake of drug
اسلاید ۶: Scope of Medicine-For treatment of disease-For improving use of other medicine-For prevention of disease-For enhancement of “quality of life” of patients and “healthy” individuals
اسلاید ۷: The Current Paradigm of Mainstream Pharmaceutical DiscoveryReductionist approachTo identify a target associated with diseaseTo identify a single compound that can regulate a given target associated with a disease. Such compounds are expected to have potency and selectivity for the treatment of the disease targeted.
اسلاید ۸: Challenges of Current Mainstream Drug Discovery ApproachFor a given disease, it can be caused by multiple reasons, it will be difficult to find one chemical with defined target related to diseases- To treat the majority of patients- To prevent a majority of the population contracting the diseaseFor a given treatment, multiple side effects could occur, it will be difficult to find one drug to relieve all the side effectsFor different patients with the same disease caused by the same etiological factor, the response to a given treatment could be different. Host factors need to be taken into considerationMany of potent drugs for the treatment or prevention of chronic diseases may require long-term use, delayed toxicity may occur
اسلاید ۹: New Paradigm for Future MedicineMultiple targetsPolychemical medicine instead of one chemical medicine with system biology approach in mind
اسلاید ۱۰: Two Approaches to Polychemical MedicineConventional “Step by step”Revisiting history as the basis of reinventing medicineTraditional Chinese medicine and other Folk medicine
اسلاید ۱۱: Chinese herbal medicine has many chemicals which could target on multiple sites or act on a single site additively or synergistically through direct or indirect interaction.پاورپوینت کامل Chinese Medicine 50 اسلاید در PowerPoint has multiple medical usage for the treatment of complicated diseases or multiple symptoms as well as disease prevention and improving quality of life.پاورپوینت کامل Chinese Medicine 50 اسلاید در PowerPoint takes a holistic approach and is an early form of “system biology” and “integrated medicine”.پاورپوینت کامل Chinese Medicine 50 اسلاید در PowerPoint is prescribed on an individual basis to optimize its usage. It is “individualized medicine”.پاورپوینت کامل Chinese Medicine 50 اسلاید در PowerPoint Could Meet Some of the Current Unmet Medical Needs and Serve as the Basis for Future Medicine”
اسلاید ۱۲: Botanical Drugs: A new area for the US FDAGuidelines for the Botanical Drug Industry: (June 2004)Waive the combination ruleMay enter Phase I,II clinical studies with a documented history of useRequirements for approval will include:SafetyEfficacyProduct Consistency“Botanical drug” and drug interactionMechanism(s) of Action(s) & Active Ingredients
اسلاید ۱۳: How to Make Preparations of Herbal Medicine with ConsistencyAuthentication of herbGood agricultural practices (GAP)Good manufacturing practices (GMP)
اسلاید ۱۴: Authentication of HerbMicro-morphological analysisGene sequence analysisChemical analysisIn vitro (solution state)In situ (solid state)
اسلاید ۱۵: Stem TissueCoated Stem TissueA schematic Diagram Showing the determination a chemical image of herbal tissue by Matrix-Assisted Laser Desorption / Ionization Mass Spectrometry (MALD-MS)
اسلاید ۱۶: Direct Desorption / Ionization of Morphinane Alkaloids from the Stem Tissue of Sinomenium acutum by MALDI By: K.M. Ng (HKU) Z. Zhao (BU) et al.
اسلاید ۱۷: ۰۳۱۱۰۰۷ and 0311008 are two different samples from Shaaپاورپوینت کامل Chinese Medicine 50 اسلاید در PowerPointi province 0311011 and 0312032 are from Anhui province and Chongqin city, respectively. K.M. Ng et al. (Unpublished Results)Spatial distribution of two metabolites from within stem tissue of Sinomenium acutum collected from different growing areas
اسلاید ۱۸: Good Agricultural Practices consistency of raw ingredientsBotanical authenticationMacro and micro histologyAgricultural contaminantsHeavy metals, pesticides, fungicides, herbicides …Bacterial, plant
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