پاورپوینت کامل Herbal pharmacology and Drug interaction of the Herbs that Remove Blood Stasis 63 اسلاید در PowerPoint

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پاورپوینت کامل Herbal pharmacology and Drug interaction of the Herbs that Remove Blood Stasis 63 اسلاید در PowerPoint

اسلاید ۴: (۲)Improve hematology and against coagulation Blood stasis is related to thrombus formation due to “thickness, stickiness, coagulation and accumulation” of blood in circulation. Most of the herbs that remove blood stasis have excellent function of improving the tendency of “thickness, stickiness, coagulation and accumulation” of blood in circulation. They have inhibitory influence on thrombus formation, and are used in treatment of angina, embolism and stroke. The herbs include Dan Shen(Radix Salviae Mitiorrhizae), Chuan Xiong(Rhizoma Ligustici Chuaپاورپوینت کامل Herbal pharmacology and Drug interaction of the Herbs that Remove Blood Stasis 63 اسلاید در PowerPointiong), Hong Hua(Flos Carthami).

اسلاید ۵: (۳)Dilate blood vessel and increase blood perfusion to small vessels. The herbs that dilate coronary arteries include Shui Zhi(Hirudo), E Zhu(Rhizoma Curcumae), Tao Ren(Semen Persicae), Chuan Xiong(Rhizoma Ligustici Chuaپاورپوینت کامل Herbal pharmacology and Drug interaction of the Herbs that Remove Blood Stasis 63 اسلاید در PowerPointiong)(4)Antineoplastic: Some of the herbs can inhibit the growth of cancer cells in vitro. The examples are San Leng(Rhizoma Sparganii), E Zhu(Rhizoma Curcumae), Sanqi (Panax notoginseng).

اسلاید ۶: (۵)Lower cholesterol The herbs are Sanqi (Panax notoginseng), Dan Shen (Radix Salviae Mitiorrhizae), Pu Huang(Pollen Typhae).2. Potential Herb-drug Interactions (3)(1)Antiplatelets and anticoagulants: The group herbs may enhance the actions of antiplatelets and anticoagulants medications, and prolong bleeding, such as warfarin, heparin, lepirudin, salicylate .

اسلاید ۷: (۲)Antihypertensives: Some of the group of herbs may dilate the blood vessels, which may potentiate the effect of antihypertensiv medications.Reference1.Qian Xin-zhong. Chinese Materia Medica. People’s Medical Publishing House. 2007.Beijing2. Shen Yin-jun. Chinese Herbal Pharmacology. People’s Medical Publishing House. 2000.Beijing3. John Chen, Tina T Chen. Chinese Medical Herbology and Pharmacology. Art of Medicine Press, Inc. 20 of Industry, CA.

اسلاید ۸: Dan Shen(Radix Salviae Mitiorrhizae)

اسلاید ۹: NewsBEIJING, Aug. 7 (Xinhua) — A China-made pill to treat cardiovascular conditions has been tested safe and effective by the U.S. Food and Drug Administration (FDA), and, hopefully, will be marketed in the U.S. as early as 2013, a pharmaceutical company said here Saturday. (http://news.xi/english2010/china/2010-08/07/c_13434173.htm)FDA reports: Dan Shen and Ge Gen are in clinical trial-Phase II:Cardiovascular-Protective Effects of Herbal Medicine Danshen-Gegen(http://clinicaltrials.gov/ct2/show/NCT01033630term=Danshen&rank=1)Dan shen

اسلاید ۱۰: Dan Shen is the root and rhizome of salvia miltiorrhiza Bge., family Labiatae.Properties: Bitter and slightly coldChannels entered: Heart, pericardium, and liver 1. Actions and indications (1) Actions and indications in TCM (1) Invigorates the blood and breaks up blood stasis: It is used for blood stasis disorders in lower abdomen such as dysmenorrhea, amenorrhea, masses. It is also used for Chest pain.Dan shen

اسلاید ۱۱: Dan shen (2)Clears heat and smoothes irritabilityIt is used for restlessness, irritability, palpitation.(3)Cools blood and expels pusIt is used for heat in the blood level, skin sores due to toxic heat.

اسلاید ۱۲: ۲. Chemical Ingredients in Danshen(2,3,4)Dan Shen has more than 50 compounds: Tanshinone, TanshinoneA, Tanshinone B, Cryptotanshinone, Cryptotanshinone, Danshensu(Salviania acid A), Isotanshinone, Isotanshinone, Isocryptotanshinone, Tanshinol, Tanshinol. Methyl tanshinonate, hydroxytanshinone B , Vitamine E.Dan shen

اسلاید ۱۳: ۳.Pharmacokinetics(5) Major components absorbed rapidly after oral administration Metabolized extensively by liver Excreted from stool and urine, Some components have low short half life, low bioavailability, because of extensive metabolism Dan shen

اسلاید ۱۴: Dan Shen4. Actions and indications in Herbal pharmacologyDanshensu(6,7,8,9)Dilates coronary arteries, inhibits platelet aggregation, improves microcirculation, and protects the myocardium from reperfusion injury of the ischemic heart.Mechanisms: – prevent intracellular calcium increase – remove oxygen free radicals – Inhibit myocardial cell apoptosis – protect the endothelial cells against homocysteinemia (risk factor for cardiovascular diseases and atherosclerosis)

اسلاید ۱۵: Salvianolic Acid B(10, 11)Protect the brain from ischemia-reperfusion injuryMechanisms:-Inhibit platelet aggregation and oxidative modification of lowdensity lipoprotein(LDL), leading to the prevention of the uptake of LDL(12,13).-Inhibit erythrocyte hemolysis and lipid peroxide production(14) -Inhibit DNA synthesis of noncardiomyocytes and inhibit stress-activated protein kinase activity, leading to protection of ischemia-reperfusion injury (15)Dan shen

اسلاید ۱۶: Tanshinone IIAReduce myocardial infarct size(16).-Inhibit LDL oxidation and angiotensin II activity, resulting in attenuation of cardiac cell hypertrophy.The other actions:Prevent cancer metastasis(17)Tanshinone II-A significantly inhibited in vivo metastasis of colon carcinoma SW480 cells. It inhibited in vitro and in vivo invasion and metastasis of colon carcinoma cells by reducing levels of urokinase plasminogen activator (uPA) and matrix metalloproteinases (MMP)-2 and MMP-9, and by increasing levels of tissue inhibitor of matrix metalloproteinase protein (TIMP)-1 and TIMP-2. Tanshinone II-A was also shown to suppress the nuclear factor-kappaB (NF-kappaB) signal.Dan shen

اسلاید ۱۷: Protect the liver injury(18)Clinic researches:1. Angina Pectoris-Danshen products were found to be better than isosorbide dinitrate(ISDN) for long term use-None of the Danshen products was found to be superior in efficiency to nitroglycerin, fewer side effects such as headache were found in Danshen group compared to that in the nitroglycerin group(19).-Danshen dripping pill was found to achieve a higher rate of effectiveness in treating patients with angina pectoris in comparison to the Danshen Tablet.-Fufang Danshen Spray and injection were similar or better efficacy when compared to ISDN(20)Dan shen

اسلاید ۱۸: -The improvement of exercise ECG from the Fufang Danshen Dripping Pill was found to be significantly better than ISDN.-The sublingual Fufang Danshen Dripping Pill is at least as effective as sublingual ISDN and comparable to sublingual nitroglycerin(21)2. Hyperlipidemia(22) -Danshen products can reduce the level of cholesterol, triglyceride, and LDL, and raised the level of HDL. Dan shen

اسلاید ۱۹: ۳. Acute Ischemic Stroke(23,24) -Improve the short-term effect of acute stroke patients-conducive to the recovery of patients with traumatic intracranial hematoma (TICH)-improves the microcirculation of femoral head, which is beneficial to repair and reconstruction of femoral head.Dan shen

اسلاید ۲۰: Side effects(25) No major side effects Patients who are taking Fufang Danshen Dripping Pill may felt thirsty(3/100), dizziness, drowsiness, abdominal discomfort(2/34), decrease appetite and itching.LD50 of water soluble extract was almost 4000 times higher in mice than the clinical human oral dosage.Dan shen

اسلاید ۲۱: HERB-DRUG INTERACTION1. The anticoagulant response to warfarin could be exaggerated when coadministered with Danshen (26,27). 2. Salicylate in therapeutic concentration was reported to be significantly decrease free Danshen concentration as measured by free-digoxin-like activity(28